Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.

ABSTRACT: Signaling by the G-protein-coupled receptors (GPCRs) plays fundamental role in a vast number of essential physiological functions. Precise control of GPCR signaling requires action of regulators of G protein signaling (RGS) proteins that deactivate heterotrimeric G proteins. RGS proteins are elaborately regulated and comprise multiple domains and subunits, yet structural organization of these assemblies is poorly understood. Here, we report a crystal structure and dynamics analyses of the multisubunit complex of RGS7, a major regulator of neuronal signaling with key roles in controlling a number of drug target GPCRs and links to neuropsychiatric disease, metabolism, and cancer. The crystal structure in combination with molecular dynamics and mass spectrometry analyses reveals unique organi

SUBMITTER: Patil DN 

PROVIDER: S-EPMC6310461 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature