CLDN10 single nucleotide polymorphism rs1325774 alters the risk of breast cancer in south chinese women.

ABSTRACT: Breast cancer is one of the most widespread malignancies in females, and the incidence rate has been increasing in recent years in the world. Genetic factors play an important role in the occurrence of breast cancer. Our study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of claudin 10 (CLDN10) (rs1325774, rs7333503, rs3751334) and breast cancer and the clinical characteristics of patients.A total of 104 patients with breast cancer and 118 healthy controls were recruited in our study between 2013 and 2015. The SNPscan system was used for genotyping. Demographic information, health status, anthropometric parameters and clinical data were considered in analysis. Statistical analysis of the data was carried out using the Student t test, the Chi-square te

SUBMITTER: Liao J 

PROVIDER: S-EPMC6310520 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature