Effect of sertraline in the treatment and prevention of poststroke depression: A meta-analysis.

ABSTRACT:

Background

Morbidity of poststroke depression (PSD) remains high worldwide. Additionally, PSD causes multiple sequelae. Although sertraline has been reported to be effective in treating PSD, many studies remain inconsistent.

Methods

PubMed, Embase, Scopus, Cochrane Central Register of Controlled Trials, Clinical trials. gov, Wan fang Data (Chinese), VIP (Chinese), and CNKI (Chinese) were retrieved from inception to April 2017. Randomized controlled trials (RCTs) and self-controlled trials (SCTs) were recruited, which met the inclusion criteria in our study. The depression rating scores, the incidence of PSD, activities of daily living (ADL), neurological impairment scores, and adverse effects were assessed.

Results

Around 11 studies were recruited in our work, includi

SUBMITTER: Feng R 

PROVIDER: S-EPMC6310584 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature