Improving vaccines against Streptococcus pneumoniae using synthetic glycans.

ABSTRACT: Streptococcus pneumoniae remains a deadly disease in small children and the elderly even though conjugate and polysaccharide vaccines based on isolated capsular polysaccharides (CPS) are successful. The most common serotypes that cause infection are used in vaccines around the world, but differences in geographic and demographic serotype distribution compromises protection by leading vaccines. The medicinal chemistry approach to glycoconjugate vaccine development has helped to improve the stability and immunogenicity of synthetic vaccine candidates for several serotypes leading to the induction of higher levels of specific protective antibodies. Here, we show that marketed CPS-based glycoconjugate vaccines can be improved by adding synthetic glycoconjugates representing serotypes th

SUBMITTER: Kaplonek P 

PROVIDER: S-EPMC6310808 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature