Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish Danio rerio.

ABSTRACT: The global prevalence of depression is high during childbearing. Due to the associated risks to the mother and baby, the selective serotonin reuptake inhibitor fluoxetine (FLX) is often the first line of treatment. Given that FLX readily crosses the placenta, a fetus may be susceptible to the disruptive effects of FLX during this highly plastic stage of development. Here, we demonstrate that a 6-day FLX exposure to a fetus-relevant concentration at a critical developmental stage suppresses cortisol levels in the adult zebrafish (F₀). This effect persists for three consecutive generations in the unexposed descendants (F₁ to F₃) without diminution and is more pronounced in males. We also show that the in vivo cortisol response of the interrenal (fish "adrenal

SUBMITTER: Vera-Chang MN 

PROVIDER: S-EPMC6310822 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature