Defective respiration and one-carbon metabolism contribute to impaired naive T cell activation in aged mice.

ABSTRACT: T cell-mediated immune responses are compromised in aged individuals, leading to increased morbidity and reduced response to vaccination. While cellular metabolism tightly regulates T cell activation and function, metabolic reprogramming in aged T cells has not been thoroughly studied. Here, we report a systematic analysis of metabolism during young versus aged naïve T cell activation. We observed a decrease in the number and activation of naïve T cells isolated from aged mice. While young T cells demonstrated robust mitochondrial biogenesis and respiration upon activation, aged T cells generated smaller mitochondria with lower respiratory capacity. Using quantitative proteomics, we defined the aged T cell proteome and discovered a specific deficit in the induction of enzymes of one-carbon

SUBMITTER: Ron-Harel N 

PROVIDER: S-EPMC6310842 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature