Computer-assisted prediction of clinical progression in the earliest stages of AD.

ABSTRACT:

Introduction

Individuals with subjective cognitive decline (SCD) are at increased risk for clinical progression. We studied how combining different diagnostic tests can help to identify individuals who are likely to show clinical progression.

Methods

We included 674 patients with SCD (46% female, 64 ± 9 years, Mini-Mental State Examination 28 ± 2) from three memory clinic cohorts. A multivariate model based on the Disease State Index classifier incorporated the available baseline tests to predict progression to MCI or dementia over time. We developed and internally validated the model in one cohort and externally validated it in the other cohorts.

Results

After 2.9 ± 2.0 years, 151(22%) patients showed clinical progression. Overall performance of the classifier when c

SUBMITTER: Rhodius-Meester HFM 

PROVIDER: S-EPMC6310913 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature