Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms.

ABSTRACT:

Background

Intracranial aneurysms (IAs) are dangerous because of their potential to rupture and cause deadly subarachnoid hemorrhages. Previously, we found significant RNA expression differences in circulating neutrophils between patients with unruptured IAs and aneurysm-free controls. Searching for circulating biomarkers for unruptured IAs, we tested the feasibility of developing classification algorithms that use neutrophil RNA expression levels from blood samples to predict the presence of an IA.

Methods

Neutrophil RNA extracted from blood samples from 40 patients (20 with angiography-confirmed unruptured IA, 20 angiography-confirmed IA-free controls) was subjected to next-generation RNA sequencing to obtain neutrophil transcriptomes. In a randomly-selected training cohor

SUBMITTER: Tutino VM 

PROVIDER: S-EPMC6310942 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature