A genome wide SNP genotyping study in the Tunisian population: specific reporting on a subset of common breast cancer risk loci.

ABSTRACT:

Background

Breast cancer is the most common cancer in women worldwide. Around 50% of breast cancer familial risk has been so far explained by known susceptibility alleles with variable levels of risk and prevalence. The vast majority of these breast cancer associated variations reported to date are from populations of European ancestry. In spite of its heterogeneity and genetic wealth, North-African populations have not been studied by the HapMap and the 1000Genomes projects. Thus, very little is known about the genetic architecture of these populations.

Methods

This study aimed to investigate a subset of common breast cancer loci in the general Tunisian population and to compare their genetic composition to those of other ethnic groups. We undertook a genome-wide haplotype

SUBMITTER: Hamdi Y 

PROVIDER: S-EPMC6310952 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature