Plasma mitochondrial DNA and metabolomic alterations in severe critical illness.

ABSTRACT:

Background

Cell-free plasma mitochondrial DNA (mtDNA) levels are associated with endothelial dysfunction and differential outcomes in critical illness. A substantial alteration in metabolic homeostasis is commonly observed in severe critical illness. We hypothesized that metabolic profiles significantly differ between critically ill patients relative to their level of plasma mtDNA.

Methods

We performed a metabolomic study with biorepository plasma samples collected from 73 adults with systemic inflammatory response syndrome or sepsis at a single academic medical center. Patients were treated in a 20-bed medical ICU between 2008 and 2010. To identify key metabolites and metabolic pathways related to plasma NADH dehydrogenase 1 (ND1) mtDNA levels in critical illness, we first

SUBMITTER: Johansson PI 

PROVIDER: S-EPMC6310975 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature