Proteomics and multivariate modelling reveal sex-specific alterations in distinct regions of human carotid atheroma.

ABSTRACT:

Background

Atherosclerotic lesions are comprised of distinct regions with different proteomic profiles. Men and women develop differences in lesion phenotype, with lesions from women generally being more stable and less prone to rupture. We aimed to investigate the differences in proteomic profiles between sexes, including distinct lesion regions, to identify altered proteins that contribute to these differences observed clinically.

Methods

Carotid endarterectomy samples (ten men/ten women) were obtained, and intraplaque biopsies from three distinct regions (internal control, fatty streak and plaque) were analysed by tandem-mass spectrometry. Multivariate statistical modelling, using orthogonal partial least square-discriminant analysis, was used to discriminate the proteome

SUBMITTER: Ward LJ 

PROVIDER: S-EPMC6311011 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature