First insights on the genetic diversity of MDR Mycobacterium tuberculosis in Lebanon.

ABSTRACT:

Background

Lebanon hosts a heterogeneous population coming from underdeveloped and developing countries, resulting in increasing incidences of tuberculosis over the past years. The genetic heterogeneity and lineages associated with tuberculosis, along with their resistance determinants have not been studied at the genomic level previously in the region.

Methods

Isolates were recovered from the American University of Beirut Medical Center (AUBMC). Antimicrobial susceptibility profiles were determined using the MGIT automated system for the first-line drugs at AUBMC, while second-line drug susceptibility was tested at Mayo Clinic Laboratories. Whole Genome Sequencing (WGS) was performed to classify mycobacterial lineages and highlight single nucleotide mutations causing resist

SUBMITTER: Panossian B 

PROVIDER: S-EPMC6311033 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature