DNA Thioaptamer with Homing Specificity to Lymphoma Bone Marrow Involvement.

ABSTRACT: Selective drug accumulation in the malignant tissue is a prerequisite for effective cancer treatment. However, most drug molecules and their formulated particles are blocked en route to the destiny tissue due to the existence of multiple biological and physical barriers including the tumor microvessel endothelium. Since the endothelial cells on the surface of the microvessel wall can be modulated by inflammatory cytokines and chemokines secreted by the tumor or stromal cells, an effective drug delivery approach is to enhance interaction between the drug particles and the unique spectrum of surface proteins on the tumor endothelium. In this study, we performed in vivo screening for thioaptamers that bind to the bone marrow endothelium with specificity in a murine model of lymphoma with bone

SUBMITTER: Mai J 

PROVIDER: S-EPMC6311132 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature