Implications of reconstruction protocol for histo-biological characterisation of breast cancers using FDG-PET radiomics.

ABSTRACT:

Background

The aim of this study is to determine if the choice of the ¹⁸F-FDG-PET protocol, especially matrix size and reconstruction algorithm, is of importance to discriminate between immunohistochemical subtypes (luminal versus non-luminal) in breast cancer with textural features (TFs).

Procedures

Forty-seven patients referred for breast cancer staging in the framework of a prospective study were reviewed as part of an ancillary study. In addition to standard PET imaging (PSF_WholeBody), a high-resolution breast acquisition was performed and reconstructed with OSEM and PSF (OSEM_breast/PSF_breast). PET standard metrics and TFs were extracted. For each reconstruction protocol, a prediction model for tumour classification was built u

SUBMITTER: Aide N 

PROVIDER: S-EPMC6311169 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature