Lupinus mutabilis Edible Beans Protect against Bacterial Infection in Uroepithelial Cells.

ABSTRACT: Lupinus mutabilis is a South American herb with edible beans, known to reduce serum glucose levels in diabetic patients. Furthermore, L. mutabilis contains phytochemicals known to decrease bacterial load. Based on the increased urinary tract infections experienced among patients with diabetes, we investigated the effect of L. mutabilis on bladder epithelial cells in the protection of E. coli infection during normal and high glucose concentrations. We did not observe any direct antibacterial effect by L. mutabilis extract. Instead we observed an influence on the host cells, with indirect impact on bacteria and their possibility of causing infection. L. mutabilis extract decreased adhesion to bladder epithelial cells of uropathogenic bacteria, includ

SUBMITTER: Kamolvit W 

PROVIDER: S-EPMC6311276 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature