Methionine Binding to Dirhodium(II) Tetraacetate.

ABSTRACT: The reaction between antitumor active dirhodium(II) tetraacetate and dl-methionine (HMet) was followed in aqueous solution and showed initially mixtures of 1:1 and 1:2 adducts [Rh₂(AcO)₄(HMet)(H₂O)] (AcO^- = CH₃COO^-) and [Rh₂(AcO)₄(HMet)₂] formed at room temperature (RT), as evidenced by UV-vis spectroscopy and electrospray ionization mass spectrometry (ESI-MS). Rh K-edge extended X-ray absorption fine structure (EXAFS) spectroscopy confirmed methionine thioether binding to the axial positions of the Rh₂(AcO)₄ cage structure. With excess HMet at RT, stepwise displacement of the acetate groups was observed after some time using ESI-MS. Heating the solution to 40° for 24 h

SUBMITTER: Enriquez Garcia A 

PROVIDER: S-EPMC6311416 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature