Variability of urinary concentrations of phthalate metabolites during pregnancy in first morning voids and pooled samples.

ABSTRACT:

Background

Because phthalates are quickly metabolized and excreted in urine, and human exposures tend to be episodic, phthalate metabolite concentrations measured in a maternal spot urine sample are only indicative of recent exposure.

Objective

To examine temporal variability of pregnant women's phthalate exposure using multiple first morning voids (FMV) and pooled samples.

Methods

We quantified 14 metabolites of eight phthalates in 577 urine samples collected from 188 pregnancies in the MARBLES (Markers of Autism Risk in Babies - Learning Early Signs) study. We calculated intraclass correlation coefficients (ICCs) using two samples of the same urine type (i.e., two FMVs or two pools) collected across the 2nd and 3rd trimesters. We also calculated ICCs and FMV/pool co

SUBMITTER: Shin HM 

PROVIDER: S-EPMC6311426 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature