Association of rs1042522 SNP with Clinicopathologic Factors of Breast Cancer Patients in the Markazi Province of Iran.

ABSTRACT:

Background

The nucleotide changes in different genetic loci increased the incidence risk of breast cancer.

Aim

The aim of present study was to investigate genotype distribution at codon 72 of the TP53 gene (rs1042522) in breast cancer patients to achieve a potential diagnostic marker related to some demographic feathers.

Methods

In our case-control study, blood samples were collected from a total of 34 patients harboured breast cancer. DNA was extracted, and nested-PCR was performed. Products were digested with AccII and subsequently were sequenced. Results were compared with samples characteristics.

Results

The PCR results indicated the correct implementation of extraction and amplification protocol. The genotypic distribution at codon 72 of TP53 in control gr

SUBMITTER: Anoushirvani AA 

PROVIDER: S-EPMC6311483 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature