The cyclic nucleotide-binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg²⁺ efflux activity.

ABSTRACT: Proteins of the cyclin M family (CNNMs; also called ancient conserved domain proteins, or ACDPs) are represented by four integral membrane proteins that have been proposed to function as Mg²⁺ transporters. CNNMs are associated with a number of genetic diseases affecting ion movement and cancer via their association with highly oncogenic phosphatases of regenerating liver (PRLs). Structurally, CNNMs contain an N-terminal extracellular domain, a transmembrane domain (DUF21), and a large cytosolic region containing a cystathionine-β-synthase (CBS) domain and a putative cyclic nucleotide-binding homology (CNBH) domain. Although the CBS domain has been extensively characterized, little is known about the CNBH domain. Here, we determined the first crystal structures of the CNBH domain

SUBMITTER: Chen YS 

PROVIDER: S-EPMC6311497 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature