Understanding the Role of Exercise in Cancer Cachexia Therapy.

ABSTRACT: Cachexia, the unintentional loss of body weight, is prevalent in many cancer types, and the associated skeletal muscle mass depletion increases patient morbidity and mortality. While anorexia can be present, cachexia is not reversible with nutritional therapies alone. Pharmacological agents have been proposed to treat this condition, but there are currently no approved treatments. Nonetheless, the hallmark characteristics associated with cancer cachexia remain viable foundations for future therapies. Regular physical activity holds a promising future as a nonpharmacological alternative to improve patient survival through cachexia prevention. Evidence suggests exercise training is beneficial during cancer treatment and survival. However, the mechanistic examination of cachectic skeletal mus

SUBMITTER: Hardee JP 

PROVIDER: S-EPMC6311610 | biostudies-literature | 2019 Jan-Feb

REPOSITORIES: biostudies-literature