Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

ABSTRACT: Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or completely untested. To address this issue, the Canvass library of natural products was assembled, in collaboration with academic and industry researchers, for quantitative high-throughput screening (qHTS) across a diverse set of cell-based and biochemical assays. Characterization of the library in terms of physicochemical properties, structural diversity, and similarity to compounds in publicly available libraries indicates that the Canvass library contains many structural elements in common with approved drugs. The assay data generated were anal

SUBMITTER: Kearney SE 

PROVIDER: S-EPMC6311695 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature