Oxidative Stress in Cardiac Tissue of Patients Undergoing Coronary Artery Bypass Graft Surgery: The Effects of Overweight and Obesity.

ABSTRACT:

Background

Obesity is one of the major cardiovascular risk factors and is associated with oxidative stress and myocardial dysfunction. We hypothesized that obesity affects cardiac function and morbidity by causing alterations in enzymatic redox patterns.

Methods

Sixty-one patients undergoing coronary artery bypass grafting (CABG) were included in the study. Excessive right atrial myocardial tissue emerging from the operative connection to the extracorporeal circulation was harvested. Patients were assigned to control (n = 19, body mass index (BMI): <25 kg/m²), overweight (n = 25, 25 kg/m² < BMI < 30 kg/m²), or obese (n = 17, BMI: >30 kg/m²) groups. Oxidative enzyme systems were studied directly in the cardiac m

SUBMITTER: Gramlich Y 

PROVIDER: S-EPMC6311809 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature