Effect of Potent P2Y₁₂ Inhibitors on Ventricular Arrhythmias and Cardiac Dysfunction in Coronary Artery Disease: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Previous studies have shown that P2Y₁₂ receptor inhibitors might prevent ventricular arrhythmias and cardiac dysfunction in patients with coronary artery disease. However, few studies have focused on comparison of the efficacy of novel oral potent P2Y₁₂ receptor inhibitors with clopidogrel on these outcomes.

Methods and results

We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) that were published in electronic databases of MEDLINE, EMBASE, Cochrane Central Register of Clinical Trials, and ClinicalTrials.gov before June 20, 2018. We compared the effect of prasugrel and ticagrelor with clopidogrel on outcomes of ventricular tachycardia (VT), ventricular fibrillation (VF), heart failure (HF), and cardiogen

SUBMITTER: Wang C 

PROVIDER: S-EPMC6311824 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature