A unified solution for different scenarios of predicting drug-target interactions via triple matrix factorization.

ABSTRACT:

Background

During the identification of potential candidates, computational prediction of drug-target interactions (DTIs) is important to subsequent expensive validation in wet-lab. DTI screening considers four scenarios, depending on whether the drug is an existing or a new drug and whether the target is an existing or a new target. However, existing approaches have the following limitations. First, only a few of them can address the most difficult scenario (i.e., predicting interactions between new drugs and new targets). More importantly, none of the existing approaches could provide the explicit information for understanding the mechanism of forming interactions, such as the drug-target feature pairs contributing to the interactions.

Results

In this paper, we propose a T

SUBMITTER: Shi JY 

PROVIDER: S-EPMC6311903 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature