A distinct biomolecular profile identifies monoclonal mast cell disorders in patients with idiopathic anaphylaxis.

ABSTRACT:

Background

Clonal mast cell disorders are known to occur in a subset of patients with systemic reactions to Hymenoptera stings. This observation has prompted the question of whether clonal mast cell disorders also occur in patients with idiopathic anaphylaxis (IA).

Objective

We sought to determine the prevalence of clonal mast cell disorders among patients with IA, criteria to identify those patients who require a bone marrow biopsy, and whether the pathogenesis of IA involves a hyperresponsive mast cell compartment.

Methods

We prospectively enrolled patients with IA (≥3 episodes/y) who then underwent a medical evaluation that included a serum tryptase determination, allele-specific quantitative PCR (ASqPCR) for the KIT D816V mutation, and a bone marrow examination. M

SUBMITTER: Carter MC 

PROVIDER: S-EPMC6311988 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature