Vascular endothelial cell expression of JAK2^V617F is sufficient to promote a pro-thrombotic state due to increased P-selectin expression.

ABSTRACT: Thrombosis is the main cause of morbidity and mortality in patients with JAK2^V617F myeloproliferative neoplasms. Recent studies have reported the presence of JAK2^V617F in endothelial cells of some patients with myeloproliferative neoplasms. We investigated the role of endothelial cells that express JAK2^V617F in thrombus formation using an in vitro model of human endothelial cells overexpressing JAK2^V617F and an in vivo model of mice with endothelial-specific JAK2^V617F expression. Interestingly, these mice displayed a higher propensity for thrombus. When deciphering the mechanisms by which JAK2^V617F-expressing endothelial cells promote thrombosis, we observed that they have a pro-adhesive phenotype associated wi

SUBMITTER: Guy A 

PROVIDER: S-EPMC6312008 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature