Cold storage of platelets in additive solution: the impact of residual plasma in apheresis platelet concentrates.

ABSTRACT: Platelet transfusion has become essential therapy in modern medicine. Although the clinical advantage of platelet transfusion has been well established, adverse reactions upon transfusion, especially transmission of bacterial infection, still represent a major challenge. While bacterial contamination is favored by the storage of platelets at room temperature, cold storage may represent a solution for this important clinical issue. In this study, we aimed to clarify whether plasma has protective or detrimental effects on cold-stored platelets. We investigated the impact of different residual plasma contents in apheresis-derived platelet concentrates, stored at 4°C or room temperature, on platelet function and survival. We found that platelets stored at 4°C have higher expression of apoptosi

SUBMITTER: Marini I 

PROVIDER: S-EPMC6312032 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature