Large-scale synthesis of monodisperse Prussian blue nanoparticles for cancer theranostics via an "in situ modification" strategy.

ABSTRACT:

Background

The intrinsic properties of Prussian blue (PB) nanoparticles make them an attractive tool in nanomedicine, including magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and photothermal therapy (PTT) properties. However, there still remains the challenge of their poor dispersible stability in the physiological environment. In this study, we developed an efficient hydrothermal method to address the poor dispersible stability of PB nanoparticles in the physiological environment.

Materials and methods

The concentration of H⁺, the mass of polyvinylpyrrolidone (PVP), and iron sources (K₃[Fe(CN)₆]) are very vital in the preparation of PB nanoparticles. Through exploring the preparation process, optimized PB nanoparticles (OPBs

SUBMITTER: Xu Y 

PROVIDER: S-EPMC6312061 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature