Progesterone effects on vaginal cytokines in women with a history of preterm birth.

ABSTRACT:

Objective

To determine the effect of intramuscular progesterone on the vaginal immune response of pregnant women with a history of prior preterm birth.

Methods

A prospective, cohort study of women at 11-16 weeks gestation, ≥18 years of age, and carrying a singleton pregnancy was conducted from June 2016 to August 2017 after IRB approval. Women in the progesterone arm had a history of preterm birth and received weekly intramuscular 17-hydroxyprogesterone caproate. Controls comprised of women with healthy, uncomplicated pregnancies. Excluded were women with vaginitis, diabetes mellitus, hypertension, or other chronic diseases affecting the immune response. A vaginal wash was performed at enrollment, at 26-28 weeks, and at 35-36 weeks gestation. Samples underwent semi-quantitat

SUBMITTER: Garry DJ 

PROVIDER: S-EPMC6312274 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature