Myocardial Notch1-Rbpj deletion does not affect NOTCH signaling, heart development or function.

ABSTRACT: During vertebrate cardiac development NOTCH signaling activity in the endocardium is essential for the crosstalk between endocardium and myocardium that initiates ventricular trabeculation and valve primordium formation. This crosstalk leads later to the maturation and compaction of the ventricular chambers and the morphogenesis of the cardiac valves, and its alteration may lead to disease. Although endocardial NOTCH signaling has been shown to be crucial for heart development, its physiological role in the myocardium has not been clearly established. Here we have used mouse genetics to evaluate the role of NOTCH in myocardial development. We have inactivated the unique and ubiquitous NOTCH effector RBPJ in early cardiomyocytes progenitors, and examined its consequences in cardiac developm

SUBMITTER: Salguero-Jimenez A 

PROVIDER: S-EPMC6312338 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature