Protective versus pathologic pre-exposure cytokine profiles in dengue virus infection.

ABSTRACT: BACKGROUND:Hyperendemic circulation of all four types of dengue virus (DENV-1-4) has expanded globally, fueling concern for increased incidence of severe dengue. While the majority of DENV infections are subclinical, epidemiologic studies suggest that type-cross-reactive immunity can influence disease outcome in subsequent infections. The mechanisms controlling these differential clinical outcomes remain poorly defined. METHODOLOGY/PRINCIPAL FINDINGS:Blood samples were collected from a cohort of school-aged Thai children who subsequently experienced a subclinical DENV infection or developed dengue illness. PBMC collected prior to infection were stimulated in vitro with DENV and the secretion of 30 cytokines was measured using a multiplexed, bead-based array. Significant differences were fo

SUBMITTER: Friberg H 

PROVIDER: S-EPMC6312351 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature