Mitochondrial ATP synthase β-subunit production rate and ATP synthase specific activity are reduced in skeletal muscle of humans with obesity.

ABSTRACT:

New findings

What is the central question of this study? Humans with obesity have lower ATP synthesis in muscle along with lower content of the β-subunit of the ATP synthase (β-F1-ATPase), the catalytic component of the ATP synthase. Does lower synthesis rate of β-F1-ATPase in muscle contribute to these responses in humans with obesity? What is the main finding and its importance? Humans with obesity have a lower synthesis rate of β-F₁ -ATPase and ATP synthase specific activity in muscle. These findings indicate that reduced production of subunits forming the ATP synthase in muscle may contribute to impaired generation of ATP in obesity.

Abstract

The content of the β-subunit of the ATP synthase (β-F₁ -ATPase), which forms the catalytic site of the enzym

SUBMITTER: Tran L 

PROVIDER: S-EPMC6312454 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature