Prevalence of ROS1 fusion in Chinese patients with non-small cell lung cancer.

ABSTRACT:

Background

The study was conducted to investigate the clinicopathological features and prevalence of ROS1 gene fusion in Chinese patients with non-small cell lung cancer (NSCLC).

Methods

The presence of ROS1 fusion was assessed by quantitative real-time PCR. Associations between ROS1 fusion and clinical characteristics were analyzed.

Results

In total, 6066 patients with pathologically confirmed NSCLC and ROS1 fusion test results were enrolled. The average age was 60.89 ± 10.60 years and fusion was detected in 157 (2.59%) patients. Fusion frequency was significantly correlated with age, gender, smoking status (all P < 0.001), pathology type (P = 0.017), and lymph node metastasis stage (P = 0.027). ROS1 fusion-positive patients were significantly younger (55.68 ± 11.34 

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6312842 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature