The Association of leptin with severity of non-alcoholic fatty liver disease: A population-based study.

ABSTRACT:

Background/aims

Leptin is associated with metabolic disorders, which predispose one to non-alcoholic fatty liver disease (NAFLD). The role of leptin in NAFLD pathogenesis is not fully understood. We aim to investigate the association between serum leptin level and severity of NAFLD using U.S. nationally representative data.

Methods

Data were obtained from the United States Third National Health and Nutrition Examination Survey. NAFLD was defined by ultrasound detection and severity of hepatic steatosis in the absence of other liver diseases. The severity of hepatic fibrosis was determined by NAFLD fibrosis score (NFS). We used multivariate survey-weighted generalized logistic regression to evaluate the association between leptin level and the degree of NAFLD. We also perform

SUBMITTER: Rotundo L 

PROVIDER: S-EPMC6313023 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature