Molecular Tunnels in Enzymes and Thermophily: A Case Study on the Relationship to Growth Temperature.

ABSTRACT: Developments in protein expression, analysis and computational capabilities are decisively contributing to a better understanding of the structure of proteins and their relationship to function. Proteins are known to be adapted to the growth rate of microorganisms and some microorganisms (named (hyper)thermophiles) thrive optimally at high temperatures, even above 100 °C. Nevertheless, some biomolecules show great instability at high temperatures and some of them are universal and required substrates and cofactors in multiple enzymatic reactions for all (both mesophiles and thermophiles) living cells. Only a few possibilities have been pointed out to explain the mechanisms that thermophiles use to successfully thrive under high temperatures. As one of these alternatives, the role of molecu

SUBMITTER: Gonzalez JM 

PROVIDER: S-EPMC6313320 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature