Influence of Continuous Training on Atrial Myocytes I_K1 and I_KAch and on Induction of Atrial Fibrillation in a Rabbit Model.

ABSTRACT:

Background

Elucidation of mechanisms underlying continuous training-related atrial fibrillation (AF) may inform formulation of novel therapeutic approaches and training method selection. This study was aimed at assessing mechanisms underlying continuous training-induced AF in an animal model.

Methods

Healthy New Zealand rabbits were divided into three groups (n=8 each), namely, control (C), and moderate intensity (M), and high intensity (H) continuous training according to treadmill speed. Atrial size andintrinsic and resting heart rates were measured by transthoracic echocardiography before, and 8 and 12 weeks after training. Using a Langendorff perfusion system, AF was induced by S1S2 stimulation and the induction rate was recorded. Atrial I_K1 and I_K

SUBMITTER: Yuan D 

PROVIDER: S-EPMC6313976 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature