Evaluation of the Feasibility of Screening Tau Radiotracers Using an Amyloid Biomathematical Screening Methodology.

ABSTRACT: The purpose of this study is to evaluate the feasibility of extending a previously developed amyloid biomathematical screening methodology to support the screening of tau radiotracers during compound development. 22 tau-related PET radiotracers were investigated. For each radiotracer, in silico MLogP, V _x, and in vitro K _D were input into the model to predict the in vivo K ₁, k ₂, and BP_ND under healthy control (HC), mild cognitive impaired (MCI), and Alzheimer's disease (AD) conditions. These kinetic parameters were used to simulate the time activity curves (TACs) in the target regions of HC, MCI, and AD and a reference region. Standardized uptake value ratios (SUVR) were determined from the integrated area

SUBMITTER: Nai YH 

PROVIDER: S-EPMC6314003 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature