Leveraging family history in population-based case-control association studies.

ABSTRACT: Population-based epidemiologic studies often gather information from study participants on disease history among their family members. Although investigators widely recognize that family history will be associated with genotypes of the participants at disease susceptibility loci, they commonly ignore such information in primary genetic association analyses. In this report, we propose a simple approach to association testing by incorporating family history information as a "phenotype." We account for the expected attenuation in strength of association of the genotype of study participants with family history under Mendelian transmission. The proposed analysis can be performed using standard statistical software adopting either a meta- or pooled-analysis framework. Re-analysis of a total of

SUBMITTER: Ghosh A 

PROVIDER: S-EPMC6314034 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature