Association between the SLC6A4 gene and schizophrenia: an updated meta-analysis.

ABSTRACT:

Background

In order to explore the association between the SLC6A4 gene and the risk of schizophrenia, an updated meta-analysis was conducted using a total of 46 scientific articles.

Methods

Through a literature search, papers studied included 35 articles on serotonin-transporter-linked polymorphic region (5-HTTLPR) with 8,752 cases and 10,610 controls, 17 articles on second intron variable number of tandem repeats with 7,284 cases and 8,544 controls, four studies on rs1042173 with 1,351 cases and 2,101 controls, and four studies on rs140700 with 1,770 cases and 2,386 controls. Pooled, subgroup, and sensitivity analyses were performed, and the results were visualized by forest and funnel plots.

Results

An association between 5-HTTLPR and the risk of schizophreni

SUBMITTER: Xu FL 

PROVIDER: S-EPMC6314053 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature