Granulin 1 Promotes Retinal Regeneration in Zebrafish.

ABSTRACT:

Purpose

Retinal degenerative diseases can progress to severe reductions of vision. In general, the changes are permanent in higher vertebrates, including humans; however, retinal regeneration can occur in lower vertebrates, such as amphibians and teleost fish. Progranulin is a secreted growth factor that is involved in normal development and wound-healing processes. We have shown that progranulin promotes the proliferation of retinal precursor cells in mouse retinas. The purpose of this study was to investigate the role played by granulin 1 (grn1) in the retinal regeneration in zebrafish.

Methods

We injured the retina of zebrafish with needle puncturing, and the retinas were examined at different times after the injury. We also checked the proliferation and the expression of

SUBMITTER: Tsuruma K 

PROVIDER: S-EPMC6314112 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature