A TLR4-derived non-cytotoxic, self-assembling peptide functions as a vaccine adjuvant in mice.

ABSTRACT: Vaccination is devised/formulated to stimulate specific and prolonged immune responses for long-term protection against infection or disease. A vaccine component, namely adjuvant, enhances antigen recognition by the host immune system and thereby stimulates its cellular and adaptive responses. Especially synthetic Toll-like receptor (TLR) agonists having self-assembling properties are considered as good candidates for adjuvant development. Here, a human TLR4-derived 20-residue peptide (TR-433), present in the dimerization interface of the TLR4-myeloid differentiation protein-2 (MD2) complex, displayed self-assembly and adopted a nanostructure. Both in vitro studies and in vivo experiments in mice indicated that TR-433 is nontoxic. TR-433 induced pro-inflammatory responses in

SUBMITTER: Tandon A 

PROVIDER: S-EPMC6314143 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature