Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy.

ABSTRACT:

Objective

Despite viral suppression, HIV-associated cognitive impairment persists and may be partially due to persistent immune signalling by cells of the myeloid-lineage. Here, we aimed to understand the contribution of activated microglia located in vulnerable brain regions (e.g. frontal, subcortical) of HIV-infected, virally suppressed (HIV+VS) individuals in relation to cognitive and motor function.

Design

Twenty-one HIV+VS individuals underwent PET with [11C]DPA-713 to image the translocator protein 18 kDa (TSPO), a marker of microglial activation, and completed a comprehensive neuropsychological test battery.

Methods

Multivariable linear regressions were used to examine the contribution of [11C]DPA-713 binding to cognitive performance.

Results

Higher [11C

SUBMITTER: Rubin LH 

PROVIDER: S-EPMC6314298 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature