Albumin binding, anticancer and antibacterial properties of synthesized zero valent iron nanoparticles.

ABSTRACT:

Background

Nanoparticles (NPs) have been emerging as potential players in modern medicine with clinical applications ranging from therapeutic purposes to antimicrobial agents. However, before applications in medical agents, some in vitro studies should be done to explore their biological responses.

Aim

In this study, protein binding, anticancer and antibacterial activates of zero valent iron (ZVFe) were explored.

Materials and methods

ZVFe nanoparticles were synthesized and fully characterized by X-ray diffraction, field-emission scanning electron microscope, and dynamic light scattering analyses. Afterward, the interaction of ZVFe NPs with human serum albumin (HSA) was examined using a range of techniques including intrinsic fluorescence, circular dichroism, and UV-v

SUBMITTER: Anbouhi TS 

PROVIDER: S-EPMC6314318 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature