Dataset Information

The Epidemiology of Otosclerosis in a British Cohort.

ABSTRACT: OBJECTIVE:To analyse the epidemiology of otosclerosis in a British cohort collected between 2011 and 2017. DESIGN:Retrospective cohort study. SETTING:Five UK ENT Departments. PATIENTS:Patients with surgically confirmed otosclerosis. MAIN OUTCOME MEASURES:Questionnaire data documented family history of otosclerosis, age of onset, medical history, and information on associated risk factors for 657 patients. Pre and post-surgical pure-tone audiometry was collected for 154 of these patients. RESULTS:The age of onset, incidence of bilateral disease, tinnitus and vertigo, a higher prevalence of women (65%) than men (35%) are similar to those reported previously for otosclerosis cohorts. No association with measles infection was detected. Patients with a family history (40%) have an earlier age of onset and a higher incidence of bilateral disease and vertigo than non-familial subjects. Pedigree analysis is consistent with an autosomal dominant inheritance with reduced penetrance being apparent in 44/91 pedigrees studied. Women who associate their hearing loss with pregnancy have an earlier age of onset than those that do not (p?=?6?×?10). CONCLUSIONS:This study confirms that otosclerosis is an early adult onset disease that is more prevalent in women than men with a large minority of patients having a family history of otosclerosis. We report new evidence to support a relationship between pregnancy and otosclerosis progression in a proportion of women. In addition, this is the first study to identify differences in severity between familial and non-familial cases of otosclerosis, highlighting the possibility that more than one etiology may be involved.

SUBMITTER: Crompton M

PROVIDER: S-EPMC6314447 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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The Epidemiology of Otosclerosis in a British Cohort.

Crompton Michael M Cadge Barbara A BA Ziff Joanna L JL Mowat Andrew J AJ Nash Robert R Lavy Jeremy A JA Powell Harry R F HRF Aldren Christopher P CP Saeed Shakeel R SR Dawson Sally J SJ

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20190101 1

<h4>Objective</h4>To analyse the epidemiology of otosclerosis in a British cohort collected between 2011 and 2017.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>Five UK ENT Departments.<h4>Patients</h4>Patients with surgically confirmed otosclerosis.<h4>Main outcome measures</h4>Questionnaire data documented family history of otosclerosis, age of onset, medical history, and information on associated risk factors for 657 patients. Pre and post-surgical pure-tone audiometry was collecte ...[more]

PMID: 30540696

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Project description:BackgroundContinued proliferation of accelerometers in physical activity research has opened new avenues for understanding activity behaviours beyond simple aggregate measures of frequency and duration. This study explores the standing and stepping composition, and the temporal distribution, of upright events, and investigates their associations with sociodemographic and health factors.MethodsParticipants from the 1970 British Cohort Study wore activPAL3 accelerometers for seven days. Event-based analysis was used to extract a time series of upright, standing, and stepping events. Derived metrics included daily number of upright and stepping events, total upright and stepping time, the burstiness of upright events and burstiness of sedentary events (burstiness refers to the pattern of how physical activity and sedentary behaviour are distributed throughout a given time period), within-event stepping proportion, within-event step count, and stepping cadence. Generalized linear regression models, adjusted for total step count, were employed to explore associations between derived metrics and sociodemographic and health-related factors.ResultsA total of 4527 participants, provided 30992 valid days (≥ 10 h of waking wear) and 1.64 million upright events. Upright event composition and temporal distribution varied across a range of sociodemographic and health-related factors. Females had more upright events than males (4.39 [3.41,5.38] n), spent more time upright, and exhibited burstier patterns of upright events (0.05 [0.04,0.05] Bn). Individuals with higher BMI had fewer upright events and a lower daily step count, but their temporal distribution of upright events was less bursty (overweight -0.02 [-0.02,-0.01] Bn; obese -0.03 [-0.04,-0.02] Bn), and upright events had a higher step count. People in active occupations were upright for longer, displayed burstier patterns of upright events (standing 0.04 [0.03,0.05] Bn; physical work 0.05 [0.04,0.05] Bn; heavy manual 0.06 [0.04,0.07] Bn), with more variable durations and shorter, slower paced stepping events compared with sedentary occupations.ConclusionsThis study has revealed novel phenotypes of standing and sitting that go beyond simple aggregate measures of total steps, step event duration or time between events. People with the same volume of stepping and frequency of gaps between upright events can accumulate their steps in very different ways. These differences and associations with population sub-groups, which persisted after adjustment for total stepping volume, may have important relations with functional and health outcomes. The findings lay the groundwork for future studies to investigate how different sitting and standing phenotypes can add to our understanding of the relationship between physical activity and health.

Dataset Information

The Epidemiology of Otosclerosis in a British Cohort.

Publications

The Epidemiology of Otosclerosis in a British Cohort.

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