Evaluation of midkine as a diagnostic serum biomarker in hepatocellular carcinoma.

ABSTRACT:

Purpose

To evaluate the value of serum midkine (MDK) as a diagnostic biomarker in hepatocellular carcinoma, particularly for those with negative alpha-fetoprotein (AFP) and at an early stage.

Experimental design

MDK expression in tumors was assessed by immunohistochemistry from 105 patients with hepatocellular carcinomas or liver cirrhosis. Serum MDK levels were detected by ELISA in 933 participants including hepatocellular carcinomas and hospital controls from different medical centers. Sensitivities and specificities of serum MDK in diagnosing hepatocellular carcinoma according to AFP level and Barcelona Clinic Liver Cancer (BCLC) stage were analyzed.

Results

MDK levels were significantly elevated in hepatocellular carcinoma tissues as well as serum samples. The sen

SUBMITTER: Zhu WW 

PROVIDER: S-EPMC6314491 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature