Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification.

ABSTRACT: Klebsiella pneumoniae, Escherichia coli, and other members of the Enterobacteriaceae family are common human pathogens that have acquired broad antibiotic resistance, rendering infection by some strains virtually untreatable. Enterobacteriaceae are intestinal residents, but generally represent <1% of the adult colonic microbiota. Antibiotic-mediated destruction of the microbiota enables Enterobacteriaceae to expand to high densities in the colon, markedly increasing the risk of bloodstream invasion, sepsis, and death. Here, we demonstrate that an antibiotic-naive microbiota suppresses growth of antibiotic-resistant clinical isolates of Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis by acidifying the proximal colon and triggering short chai

SUBMITTER: Sorbara MT 

PROVIDER: S-EPMC6314524 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature