Serum androgen profiles in women with premature ovarian insufficiency: a systematic review and meta-analysis.

ABSTRACT:

Objective

This meta-analysis aims to investigate serum androgen profiles (testosterone, dehydroepiandrosterone sulfate, androstenedione, and sex hormone-binding globulin) in women with premature ovarian failure and to establish if there is evidence of diminished androgen levels in these women.

Methods

Various Internet sources of PubMed, Cochrane library, and Medline were searched systematically until February, 2018. Out of a pool of 2,461 studies, after applying the inclusion/exclusion criterion, 14, 8, 10, and 9 studies were chosen for testosterone, dehydroepiandrosterone sulfate, androstenedione, and sex hormone-binding globulin, respectively, for this meta-analysis. The effect measure was the standardized mean difference with 95% confidence interval (95% CI) in a random-e

SUBMITTER: Soman M 

PROVIDER: S-EPMC6314630 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature