Genetic variants in genes related to inflammation, apoptosis and autophagy in breast cancer risk.

ABSTRACT:

Background

Inflammation contributes to breast cancer development through its effects on cell damage. This damage is usually dealt with by key genes involved in apoptosis and autophagy pathways.

Methods

We tested 206 single nucleotide polymorphisms (SNPs) in 54 genes related to inflammation, apoptosis and autophagy in a population-based breast cancer study of women of European (658 cases and 795 controls) and East Asian (262 cases and 127 controls) descent. Logistic regression was used to estimate odds ratios for breast cancer risk, and case-only analysis to compare breast cancer subtypes (defined by ER/PR/HER2 status), with adjustment for confounders. We assessed statistical interactions between the SNPs and lifestyle factors (smoking status, physical activity and body mass

SUBMITTER: Schuetz JM 

PROVIDER: S-EPMC6314637 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature