Acute renal failure in a patient with PR3-ANCA and monoclonal immunoglobulin deposition disease: Case report.

ABSTRACT:

Rationale

Acute renal failure developing over a short period of time with evidence of glomerular disease by urine sediment microscopy characterizes the clinical syndrome of rapidly progressive glomerulonephritis (RPGN), of which the most common causes are ANCA-associated glomerulonephritis (GN), immune-complex mediated GN and anti-GBM disease.

Patient concerns

This was a middle-aged gentleman who presented with acute renal failure and a positive PR3-ANCA.

Diagnosis

Renal biopsy showed an unusual combination of PR3-ANCA GN with focal crescents, monoclonal immunoglobulin deposition disease (MIDD) and mesangial IgA deposition on renal biopsy.

Interventions

Serum and urine protein electrophoresis (UPEP) and immunofixation showed no detectable monoclonal paraprotein

SUBMITTER: Cassol CA 

PROVIDER: S-EPMC6314724 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature