Cross-species systems analysis of evolutionary toolkits of neurogenomic response to social challenge.

ABSTRACT: Social challenges like territorial intrusions evoke behavioral responses in widely diverging species. Recent work has showed that evolutionary "toolkits"-genes and modules with lineage-specific variations but deep conservation of function-participate in the behavioral response to social challenge. Here, we develop a multispecies computational-experimental approach to characterize such a toolkit at a systems level. Brain transcriptomic responses to social challenge was probed via RNA-seq profiling in three diverged species-honey bees, mice and three-spined stickleback fish-following a common methodology, allowing fair comparisons across species. Data were collected from multiple brain regions and multiple time points after social challenge exposure, achieving anatomical and temporal resolut

SUBMITTER: Saul MC 

PROVIDER: S-EPMC6314924 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature